The expression of zinc finger transcription factor Trps1 (TRPS1) has been recently found to be specific for tumors of the breast. In normal skin, the expression of TRPS1 is found in outer root sheath, sebocytes and matrical cells of the hair follicle, as well as the inner luminal cells of eccrine glands. Cutaneous tumors with origin in these cell types were hypothesized to express TRPS1. Because little knowledge exists about the expression of TRPS1 in nonmelanocytic tumors of the skin; researchers from The University of Texas MD Anderson Cancer Center performed immunohistochemical (IHC) analysis of TRPS1 in different types of cutaneous tumors.
Human trophoblastic cell surface antigen 2 (Trop2) is upregulated in cancers compared to normal tissues. Researchers from the University of Texas MD Anderson Cancer Center recently aimed to assess the clinical significance of Trop2 in small bowel adenocarcinoma (SBA).
Bladder small-cell carcinoma can be divided into different subtypes depending on the expression of neuroendocrine (NE) markers such as POU2F3, NEUROD1 and ASCL1. Single-cell RNA sequencing previously found a distinct subpopulation with high expression of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (PLCG2) with pro-metastatic features and poor prognosis. The aim of a newer study was to evaluate the expression of PLCG2 in bladder NE tumors and correlate it with prognostic utility.
Researchers from the University of Pittsburgh Medical Center and affiliated organizations aimed to validate a novel marker of duodenal neuroendocrine tumors (DNETs), NKK6.2.
Researchers from Case Western Reserve University presented data from a study that aimed to investigate gut integrity, oxidized lipids and inflammatory markers associated with the pathogenesis of post-acute sequelae of COVID-19 (PASC).
The mechanisms behind the mortality associated with early antiretroviral therapy (ART) treatment in children infected perinatally with HIV are poorly understood. Researchers sought to find potential biomarkers associated with the increased mortality. They created three groups of subjects: deceased (dead HIV+, n=20), nondeceased HIV+ (HIV+, n=59) and healthy controls (n=13).
Researchers from IrsiCaixa Institute for AIDS Research presented data from a study that aimed to identify biomarkers associated with virus control during monitored antiretroviral pause (MAP) in patients with HIV.
To date, there is a lack of consensus in anal cancer screening. DNA methylation markers zing finger protein 582 (ZNF582) and achaete-scute homolog 1 (ASCL1) have been associated with anal intraepithelial neoplasia (AIN3) and anal carcinoma risk in people with HIV infection.
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